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《亚太临床营养医学》杂志2007,16(Suppl1):383-390
左旋肉碱+乙酰左旋肉碱对男性不育的治疗作用(全面综述)
XinZhouMD1,2,FangLiuMD2andSuodiZhaiMD2
北京大学第三医院药剂科
北京大学药学院临床药理系
本文收集了目前所发表的临床试验结果,全面系统地综述了左旋肉碱+乙酰左旋肉碱对男性不育的治疗作用.所引用的数据来自对医学数据库的相关临床试验结果,及9个随机对照的临床试验(RCTs)结果.所有数据的可靠性经皆经过了随机性和双盲行的分析验证.经统计学的元分析和与空白对照相比发现,联合服用左旋肉碱+乙酰左旋肉碱可显着提高怀孕率(p<,0.001),显着提高精子活动力(p等于0.04),显着提高前向精子活动力(p等于0.04)及显着降低异常形态精子数量(p<,0.00001).但对精子的数量和浓度的影响不大.结论:联合服用左旋肉碱+乙酰左旋肉碱可显着提高男性不育患者的怀孕率和精子的活动力.同时,复合左旋肉碱对男性不育患者更精确的作用值得一步的研究.
AsiaPacJClinNutr2007,16(Suppl1):383-390
EffectofL-carnitineand/orL-acetyl-carnitineinnutritiontreatmentformaleinfertility:asystematicreview
XinZhouMD1,2,FangLiuMD2andSuodiZhaiMD2
1DepartmentofPharmacy,PekingUniversityThirdHospital,Beijing,China,100083
2DepartmentofPharmacyAdministrationandClinicalPharmacy,SchoolofPharmaceuticalScience,PekingUniversity,BeijingChina,100083
TheaimofthissystematicreviewwastoquantifytheefficacyofL-carnitine(LC)and/orL-acetyl-carnitine(LAC)innutritiontreatmentformaleinfertilityaccordingtopresentclinicalevidence.Biomedicaldatabasesweresearchedtocollectrelatedclinicaltrialsandninerelevantrandomizedcontrolledtrials(RCTs)wereincluded.ThequalityoftheRCTswasassessedbasedontheirperformanceinrandomization,blinding,andallocationconcealment.Themeta-analysisparedLCand/orLACtherapytoplacebotreatmentfoundsignificantimprovementinpregnancyrate(OR等于4.10,95%CI(2.08,8.08),p<,0.0001),totalspermmotility(WMD等于7.43,95%CI(1.72,13.14),p等于0.04,forwardspermmotility(WMD等于11.83,95%CI(0.49,23.16),p等于0.04)andatypicalspermcell(WMD等于-5.72,95%CI(-7.89,-3.56),p<,0.00001).However,nosignificantdifferencewaoundinthespermconcentration(WMD等于5.69,95%CI(-4.47,15.84),p等于0.27)andsemenvolume(WMD等于0.28,95%CI(-0.02,0.58),p等于0.07).Inconclusion,theadministrationofLCand/orLACmaybeeffectiveinimprovingpregnancyrateandspermkiicfeaturesinpatientsaffectedbymaleinfertility.However,theexactefficacyofcarnitinesonmaleinfertilityneedstobeconfirmedbyfurtherinvestigations.